From mid August, Israel became the first nation to offer a third dose of vaccine as a booster jab to people over the age of 50. Other Nations are set to follow suit including the UK. However, this policy raises a number of serious questions on whether we should use booster shots or coronavirus itself to top up immunity in adults, and whether children should ever be vaccinated. Both have become very contentious issues which need to be widely publicised and debated.
There are marked differences in our immune systems after natural infection with coronavirus compared with acquired immunity after full vaccination. Which is better? Even asking this question a year ago bordered on heresy, when catching Covid for the first time could be deadly, especially for the elderly or people already in poor health. Now, we are no longer starting with zero immunity as the overwhelming majority of people have either been vaccinated or have already caught the virus. “We could be digging ourselves into a hole, for a very long time, where we think we can only keep Covid away by boosting every year,” Prof Eleanor Riley, an immunologist from the University of Edinburgh. Prof Adam Finn, a government vaccine adviser, said over-vaccinating people, when other parts of the world had none, was “a bit insane, it’s not just inequitable, it’s stupid”.
The anatomy of immunity
We need to understand a little bit about the key building blocks of both our immune system and the virus it is attacking. The power-couple of the immune system that clears the body of infection are antibodies and T-cells. Antibodies stick to the surface of the virus and mark it for destruction. T-cells can spot which of our own cells have been hijacked by the virus and destroy them. For all the trouble the virus has caused, it is spectacularly simple. It has the famous spike protein, which is the key it uses to unlock the doorway into our body’s cells. And 28 other proteins that it needs to hijack our cells and make thousands of copies of itself. (For comparison it takes about 20,000 proteins to run the human body).
There are four key areas to compare vaccine and natural infection with the virus.
Breadth –How much of the virus the immune system learns to attack
You get a broader immune response after being infected with the virus than vaccination. Whether you’ve had Moderna or Pfizer or Oxford-AstraZeneca, your body is learning to spot just one thing – the spike protein. This is the critical part of the virus to make antibodies to, and the results – by keeping most out of hospital – have been spectacular. But having the other 28 proteins to target too, would give T-cells far more to go at. “That means if you had a serious bout of infection, you may have better immunity to any new variants that pop up as you have immunity to more than just spike,” said Prof Riley.
Strength – How well it stops infection or prevents severe disease
We know there have been cases of people catching the virus twice (re-infection) and of being vaccinated and catching Covid (known as breakthrough infection). “Neither gives you complete protection versus infection, but the immunity you get from either seems to protect you pretty well from serious illness,” said Prof Finn. Antibody levels are, on average, higher about a month after vaccination than infection. However, there is a huge gulf in antibodies between those who are asymptomatic (who don’t make very much) and those who get a severe bout of Covid. The biggest immune response comes from people who caught Covid and were then vaccinated. We’re still waiting for data on what happens the other way round.
Duration – How long does protection last?
Antibody levels have been shown to decline over time, although this may not be important for preventing severe disease. The immune system remembers viruses and vaccines so it can respond rapidly when an infection is encountered. There are “memory T-cells” that linger in the body, and B-cells remain primed to produce a new flood of antibodies on demand. There is evidence of immune responses more than a year after infection and vaccine trials have also showed lasting benefit. “In terms of durability, we’re still waiting to see,” said Prof Peter Openshaw, from Imperial College London.
Location – Where in the body is the immunity?
This matters. There is a whole different suite of antibodies (known as immunoglobulin As) in the nose and lungs, compared with those (immunoglobulin Gs) that we measure in the blood. The former is more important as a barrier to infection. Natural infection, because it is in the nose rather than a jab in the arm, may be a better route to those antibodies, and nasal vaccines are being investigated too. Prof Paul Klenerman, who researches T-cells at the University of Oxford, said: “The location of an infection makes a difference even if it’s the same virus, so we would expect important differences between natural infection and vaccines.”
So we come back to the two big questions:
- do vaccinated adults need a booster jab, or is ongoing natural exposure to the virus sufficient for continued immunity ?
- do children need vaccinating at all, or does a lifetime of encountering build a good immune defence?
The idea of regularly topping up immunity throughout life is not radical in other infections, such as RSV (respiratory syncytial virus) or the four other coronaviruses that infect people and cause common cold symptoms. Each time you’re exposed, the immune system gets a little bit stronger, and this continues until old age, when the immune system starts to fail and the infections become a problem again. “This isn’t proven, but it could be a lot cheaper and simpler to let that happen than spend the whole time immunising people,” said Prof Finn, who warns we could end up “locked into a cycle of boosting” without seeing if it was necessary. However, he said the argument in children had “already been won” as “40-50% have already been infected and most weren’t ill or particularly ill”.
There are counter-arguments. Prof Riley points to long-Covid in children, and Prof Openshaw to nervousness around the long-term effects of a virus that can affect many of the body’s organs. But Prof Riley said there was potential in using vaccines to “take the edge off” Covid, followed by infection, to broaden the immune response. “We really need to consider, are we just frightening people rather than giving them the confidence to get on with their lives? We’re close to just worrying people now.” Of course, with cases continuing to rumble on, there may not be much choice. “I’m wondering whether it’s inevitable,” said Prof Klenerman, as if the virus continues to spread then “there will be this ongoing boosting effect”. click full BBC article. As this source is a well researched BBC article, hopefully these issues can be properly debated without being dismissed as conspiracy theory or misinformation.
So there we have it. We are back to the old “herd immunity” debate with a largely vaccinated adult population rather than from pursuing herd immunity prior to the vaccination programme. The question for many elderly people such as myself will be : should I have my third booster jab this autumn if is offered, or trust that getting infected with the delta variant of coronavirus will result in only mild disease. and strengthen my immune system that way ? If I refused the third booster jab, could I donate it to COVAX for distribution to third world countries ? Time will tell.